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Respiratory syncytial virus - a leading cause of hospitalisation of Australian infants and young children1 Almost every child will contract RSV by the time they are 2 years old2

Respiratory syncytial virus (RSV) is a prevalent and highly contagious virus that may compromise the lungs and airways of infants, children, and adults. RSV can be unpredictable in the very young with symptoms ranging from mild to severe, and may result in hospitalisation1,3 Surprisingly, the majority of infants requiring hospitalisation or admission to the intensive care unit (ICU) were previously healthy.2

In Australia, temperate regions typically experience seasonal RSV outbreaks in the autumn and winter months, with peaks usually occurring in June and July.4 This pattern typically precedes the peak of influenza cases.4 However, in the northern tropical regions of Australia, RSV activity aligns with the rainy season and increased humidity, which spans from December to March. As a result, the seasonality of RSV varies across different states and territories.4  Non-pharmaceutical measures such as mask wearing and social distancing implemented during the COVID-19 pandemic disrupted the previously predictable RSV seasonality in Australia.4

RSV is the most common viral cause of bronchiolitis in infants and young children and in severe cases, lead to hospitalisation1,5Example Text

RSV is a leading cause of pneumonia and bronchiolitis in babies and young children, resulting in more hospitalisations than influenza.1

In Australia, RSV results in over 15,000 hospital admissions for infants and young children <5 years of age annually. Almost 12,000 of these hospitalisations are for infants below 12 months of age.5

A RSV infection when young may lead to recurrent wheezing episodes in infants and young children.6Example TextRSV disease burden

A recent systematic review of 481 studies across 58 countries estimated that, in 2019, children 5 years and younger with an RSV infection accounted for7

  • 33 million RSV-associated acute lower respiratory infection (ALRI) episodes
  • 3.6 million hospitalisations due to RSV-associated ALRI
  • 26,300 RSV-associated ALRI in-hospital deaths
  • 1 in every 50 deaths of children 5 years and younger (mostly in developing countries) 


In Australia, RSV became a nationally notifiable disease on 1 July 2021.8 According to the National Notifiable Diseases Surveillance System, in 2024, over 160,000 cases have been reported year to date (October), with 50% of cases in children under the age of four.8

An Australian study estimating the incidence of RSV-associated hospitalisation found:9

  • In children under the age of 5, the incidence rate of RSV was 418 per 100,000
  • In infants under the age of 6 months, the incidence rate was 2,253 per 100,000
  • Indigenous infants are twice as likely to be hospitalised for RSV as non-Indigenous Australians
Who is most at risk?

While most babies who require hospitalisation for RSV infection are otherwise healthy, there are a number of risk factors associated with an increased risk for severe RSV disease. These factors include:2,9

  • Young age (especially infants under 3 months of age)
  • Prematurity
  • Haemodynamically-signficant congenital heart disease
  • Chronic pulmonary disease

Importantly, Indigenous infants and young children in Australia face a hospitalisation risk for RSV that is twice as high when compared to non-Indigenous babies and children.9

How is RSV spread?

RSV is highly contagious and can spread to infants and children when3,10:

  • They have close contact with sick people
  • They get virus droplets from a cough or sneeze in their eyes, nose, or mouth
  • They touch a surface that has the virus on it, like a doorknob, table, or toy, and then touch their own face before washing their hands

RSV can survive on contaminated surfaces for prolonged periods, including skin (30 minutes), fabric (2 hours), gloves (5 hours), and furniture (7 hours).1,10

 

People infected with RSV are usually contagious for 3 to 8 days. However, some infants and people with weakened immune systems can continue to spread the virus even after they stop showing symptoms, for as long as 4 weeks.11

Symptoms

RSV symptoms vary and may be similar to symptoms from other respiratory infections symptoms may range from mild and moderate to severe.3

RSV generally causes mild disease in infants and young children. However, it can become more severe in just a few days.2,3

RSV SymptomsSymptoms may include one or more of the following2,10,11 Severe RSV

Those infected with RSV may recover in a week or two.11 However, some infants and young children may suffer more severe RSV symptoms that lead to bronchiolitis, pneumonia, and in some cases hospitalisation.2

RSV can be especially serious or deadly in infants and children because it is associated with bronchiolitis that can lead to:12

  • Acute respiratory failure with severe bronchospasm
  • Moderate to severe hypoxia
  • Carbon dioxide retention, which if left untreated, can lead to death 
Diagnosis

As RSV symptoms are similar to other respiratory infections, a RSV diagnosis can be confirmed with a PCR nasopharyngeal swab.13

Management and prevention strategies

Management of RSV illness consists of supportive care including rest, maintaining fluid intake and paracetamol.2,13 For hospitalised children, management is also supportive and can include hydration, oxygen supplementation and, if needed, mechanical ventilation.2 

General infection prevention and control practices are essential to minimise the risk of RSV transmission, particularly during increased RSV circulation in the community.2

RSV is highly contagious, so it is important to take preventive measures to reduce the risk of infection:3

There are simple steps that your patients can take to reduce the transmission of RSV at home, at school, or in the workplace:3

Further information around the prevention of RSV is also available in the Australian Immunisation Handbook.

References:Nazareno AL, Muscatello DJ, Turner RM, et al. Modelled estimates of hospitalisations attributable to respiratory syncytial virus and influenza in Australia, 2009–2017. Influenza and Other Respiratory Viruses. 2022;16(6):1082-90.European Centre for Disease Prevention and Control. Intensified Circulation of respiratory syncytial virus (RSV) and associated hospital burden  in EU/EAACarvajal JJ, Avellaneda AM, Salazar-Ardiles C, Maya JE, Kalergis AM, Lay MK. Host components contributing to respiratory syncytial virus pathogenesis. Front Immunol. 2019;10:2152.Eden J-S, Sikazwe C, Xie R, et al. Off-season RSV epidemics in Australia after easing of COVID-19 restrictions. Nature Communications. 2022;13(2884):1-9.EvoHealth May 2023 Time-to-Act-protecting-our-children-from-RSV-report May 2023 MAT-AU-2300771Rosas-Salazar C, X Chirkova T, Gebretsadik T, Chappell J, Stokes Peebles Jr R, Dupont W, Jadhao,S, Gergen P, Anderson L, Hartert T. Respiratory syncytial virus infection during infancy and asthma during childhood in the USA (INSPIRE): a population based prospective birth cohort study The Lancet Volume 2023;401(10389): 1669-1680Li Y, Wang X, Blau DM, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. Lancet. 2022;399(10340):2047-2064.National Notifiable Diseases Surveillance System Data Visualisation Tool. https://www.health.gov.au/resources/apps-and-tools/national-notifiable-diseases-surveillance-system-nndss-data-visualisation-tool. Accessed October 2024Saravanos GL, Sheel M, Homaira N, et al. Respiratory syncytial virus-associated hospitalisations in Australia, 2006-2015. The Medical Journal of Australia. 2019;210(1):447-453.The Royal Children’s Hospital Melbourne Respiratory Syncytial Virus Fact Sheet 2018 https://www.rch.org.au/kidsinfo/fact_sheets/respiratory_syncytial_virus_rsv/   Accessed September 2023.National Foundation for Infectious Diseases. Respiratory syncytial virus. Updated February 2022. https://www.nfid.org/infectious-diseases/rsv/. Accessed February 2023.McNamara PS, Smyth RL. The pathogenesis of respiratory syncytial virus disease in childhood. Br Med Bull. 2002;61:13-28Better Health Channel Victoria https://www.betterhealth.vic.gov.au/respiratory-syncytial-virus-rsv#spread-of-rsv reviewed 18th May 2023, Accessed September 2023
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